PENTOBARBITAL SODIUM (NEMBUTAL) POWDER KIT

The barbiturates are nonselective central nervous system depressants which are primarily used as sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section). The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions. Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring. NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide. NEMBUTAL Sodium is a short-acting barbiturate, chemically designated as sodium 5- ethyl-5-(1-methylbutyl) barbiturate. The structural formula for pentobarbital sodium iss: The sodium salt occurs as a white, slightly bitter powder which is freely soluble in water and alcohol but practically insoluble in benzene and ether. CLINICAL PHARMACOLOGY Barbiturates are capable of producing all levels of CNS mood alteration from excitation to mild sedation, to hypnosis, and deep coma. Overdosage can produce death. In high enough therapeutic doses, barbiturates induce anesthesia. Barbiturates depress the sensory cortex, decrease motor activity, alter cerebellar ® function, and produce drowsiness, sedation, and hypnosis.
50 mg/mL CII For Intravenous or Intramuscular Use. Multiple-dose Vial. LATEX-FREE Rx only Akorn logo
Principal Display Panel Text for Carton Label: NDC 76478-501-20 20 mL Sterile Solution Nembutal Sodium Solution (pentobarbital sodium injection, USP) 50 mg/mL CII For Intravenous or Intramuscular Use. Multiple-dose Vial. LATEX-FREE. Caution: This solution is not suitable for subcutaneous administration. Rx only Akorn logo